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J Steroid Biochem Mol Biol. 2016 Nov;164:209-213. doi: 10.1016/j.jsbmb.2016.02.007. Epub 2016 Feb 11.

Vitamin D deficiency: A single centre analysis of patients from 136 countries.

Author information

1
Research & Development, VPS Healthcare, Abu Dhabi, United Arab Emirates. Electronic address: haq2000@gmail.com.
2
Department of Statistics, Faculty of Economics and Management, Czech University of Life Sciences, Prague, Kamýcká 129, 165 21, Praha 6-Suchdol, Czech Republic.
3
Medical Bioscience Programme, School of Science, Monash University, Malaysia.
4
Research & Development, VPS Healthcare, Abu Dhabi, United Arab Emirates.
5
Research & Development, VPS Healthcare, Abu Dhabi, United Arab Emirates; Department of Applied Oral Sciences, Forsyth Institute, Harvard Medical School, 245 First St, Cambridge, MA 02142, USA.

Abstract

Vitamin D deficiency is a global problem, thought to be related to lack of sunlight exposure, and usually accompanied by reduced dietary intake. This study was designed to determine vitamin D status of 60,979 patients admitted to the Burjeel Hospital of VPS healthcare in Abu Dhabi, United Arab Emirates (UAE) from October 2012 to September 2014. The total concentrations of vitamin D [25(OH)D] of all the studied patients were measured in a single laboratory. Of the studied patients, 57.5% were female and 42.5% were male. Serum 25(OH)D (total) measurements showed 82.5% of the studied patients have vitamin D deficiency to insufficiency. 26.4% of females and 18.4% of males have extreme deficiency of 25(OH)D. There was higher variability of vitamin D in group of females then males according to coefficient of variation. In our studied cohort teenagers (13-19 years) have shown the lowest levels of serum vitamin D (data not shown and will be communicated as a separate publication). The prevalence of hypovitaminosis D is significantly high among population of UAE, Saudi Arabia and many Middle Eastern countries, especially among women, despite abundant sunshine. 86.1% UAE nationals and 78.9% visitors of other nationalities were found <75nmol/L of 25(OH)D. 28.4% of UAE nationals and 17.5% of visitors of other nationalities have extreme deficiency of 25(OH)D. Our results are significant, as all of our patients are residing permanently in the UAE or visitors that has yearlong sunlight. In addition, measuring 25(OH)D concentrations in a single laboratory minimized test level variations. Our current study formed the basis of further studies to determine if vitamin D deficiency and insufficiency can aggravate systemic diseases, including hypertension, diabetes or obesity that are also wide-spread in the Middle Eastern region.

KEYWORDS:

125(OH)2D; 25(OH)D; Electrochemiluminescence; United Arab Emirates; Vitamin D deficiency

PMID:
26877203
DOI:
10.1016/j.jsbmb.2016.02.007
[Indexed for MEDLINE]

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