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J Oral Pathol Med. 2016 Oct;45(9):682-686. doi: 10.1111/jop.12434. Epub 2016 Feb 14.

Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva.

Author information

1
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
2
Department of Social and Preventive Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
3
Department of General Biology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
4
The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center Tel Hashomer and the Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
5
School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
6
Department of Pathology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
7
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. rsgomez@ufmg.br.

Abstract

BACKGROUND:

There is controversy on the effects of the non-ionizing radiation emitted by cell phones on cellular processes and the impact of such radiation exposure on health. The purpose of this study was to investigate whether cell phone use alters cytokine expression in the saliva produced by the parotid glands.

METHODS:

Cytokine expression profile was determined by enzyme linked immuno sorbent assay (ELISA) in the saliva produced by the parotid glands in healthy volunteers, and correlated with self-reported cell phone use and laterality.

RESULTS:

The following parameters were determined, in 83 Brazilian individuals in saliva produced by the parotid glands comparing the saliva from the gland exposed to cell phone radiation (ipsilateral) to that from the contralateral parotid: salivary flow, total protein concentration, interleukin 1 β (IL-1 β), interleukin 6 (IL-6), interleukin 10 (IL-10), interferon γ (IFN-γ), and tumor necrosis factor α (TNF-α) salivary levels by ELISA. After multiple testing correction, decreased IL-10 and increased IL-1β salivary levels in the ipsilateral side compared with the contralateral side (P < 0.05) were detected. Subjects who used cell phones for more than 10 years presented higher differences between IL-10 levels in ipsilateral versus contralateral parotids (P = 0.0012). No difference was observed in any of the tested parameters in correlation with cell phone monthly usage in minutes.

CONCLUSION:

The exposure of parotid glands to cell phones can alter salivary IL-10 and IL-1β levels, consistent with a pro-inflammatory microenvironment that may be related to heat production.

KEYWORDS:

inflammation; interleukin 1 β; interleukin 10; molecular alteration; non-ionizing radiation

PMID:
26876491
DOI:
10.1111/jop.12434
[Indexed for MEDLINE]

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