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J Coll Physicians Surg Pak. 2016 Feb;26(2):121-4. doi: 02.2016/JCPSP.121124.

Efficacy of 2.5% and 1.25% Povidone-Iodine Solution for Prophylaxis of Ophthalmia Neonatorum.

Author information

1
Department of Ophthalmology, Combined Military Hospital, Sargodha.
2
Department of Pathology Lab, Combined Military Hospital, Sargodha.
3
Department of Ophthalmology, Rai Medical College, Sargodha.
4
Department of Pediatrics, Combined Military Hospital, Sargodha.
5
Department of Anatomy, Rai Medical College, Sargodha.

Abstract

OBJECTIVE:

To determine the efficacy of 2.5% and 1.25% Povidone-Iodine solution for Ophthalmia neonatorum prophylaxis.

STUDY DESIGN:

Interventional study.

PLACE AND DURATION OF STUDY:

Eye Department, Combined Military Hospital, Sargodha, from May to November 2014.

METHODOLOGY:

Atotal of 200 eyes of 100 newborn babies were enrolled and divided into two groups of 100 right eyes and 100 left eyes. Aconjunctival swab for bacterial culture was taken within 30 minutes after delivery. Asingle drop of 2.5% Povidone-Iodine was then placed in the right eye while in the left eye a single drop of 1.25% Povidone-Iodine was placed. Thirty minutes after placing Povidone-Iodine, a conjunctival swab was again taken. Abacterial suspension was prepared from each swab in determining bacterial counts. The bacterial suspension was inoculated on yeast extract agar and the number of colony forming units were counted. At each culture, the number of colony forming units before and after instillation of 2.5% Povidone-Iodine and 1.25% Povidone-Iodine were compared. Wilcoxon's signed rank test was used for statistical analysis.

RESULTS:

The 2.5% Povidone-Iodine solution caused a statistically significant decrease in the number of colony forming units (p=0.001). Similarly, the 1.25% Povidone-Iodine solution also reduced the number of colony forming units to a statistically significant level (p=0.001).

CONCLUSION:

The 1.25% concentration of Povidone-Iodine is as effective as the 2.5% concentration of Povidone-Iodine in reducing the number of colony forming units in healthy conjunctivae of newborns.

PMID:
26876399
DOI:
02.2016/JCPSP.121124
[Indexed for MEDLINE]

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