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Hum Psychopharmacol. 2016 Mar;31(2):135-43. doi: 10.1002/hup.2520. Epub 2016 Feb 15.

A randomized, double-blind, placebo controlled, parallel group, efficacy study of alpha BRAIN® administered orally.

Author information

1
Boston Center for Memory, Newton, MA, USA.
2
The Memory Clinic, Bennington, VT, USA.
3
Boston University School of Medicine, Boston, MA, USA.
4
Onnit Labs LLC, Austin, TX, USA.
5
Williams College, Williamstown, MA, USA.

Abstract

OBJECTIVE:

Alpha BRAIN® is a nootropic supplement that purports to enhance cognitive functioning in healthy adults. The goal of this study was to investigate the efficacy of this self-described cognitive enhancing nootropic on cognitive functioning in a group of healthy adults by utilizing a randomized, double blind, placebo-controlled design.

METHODS:

A total of 63-treatment naïve individuals between 18 and 35 years of age completed the randomized, double-blind, placebo controlled trial. All participants completed a 2-week placebo run in before receiving active product, Alpha BRAIN® or new placebo, for 6 weeks. Participants undertook a battery of neuropsychological tests at randomization and at study completion. Primary outcome measures included a battery of neuropsychological tests and measures of sleep.

RESULTS:

Compared with placebo, Alpha BRAIN® significantly improved on tasks of delayed verbal recall and executive functioning. Results also indicated significant time-by-group interaction in delayed verbal recall for the Alpha BRAIN® group.

CONCLUSIONS:

The use of Alpha BRAIN® for 6 weeks significantly improved recent verbal memory when compared with controls, in a group of healthy adults. While the outcome of the study is encouraging, this is the first randomized controlled trial of Alpha BRAIN®, and the results merit further study.

KEYWORDS:

cognitive enhancement; nootropic; nutraceutical; randomized controlled trial

PMID:
26876224
DOI:
10.1002/hup.2520
[Indexed for MEDLINE]

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