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Trends Genet. 2016 Apr;32(4):201-210. doi: 10.1016/j.tig.2016.01.004. Epub 2016 Feb 11.

The Limits of Natural Selection in a Nonequilibrium World.

Author information

1
Department of Plant Biology, University of Minnesota, St Paul, MN 55108, USA.
2
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S 3B2, Canada. Electronic address: stephen.wright@utoronto.ca.

Abstract

Evolutionary theory predicts that factors such as a small population size or low recombination rate can limit the action of natural selection. The emerging field of comparative population genomics offers an opportunity to evaluate these hypotheses. However, classical theoretical predictions assume that populations are at demographic equilibrium. This assumption is likely to be violated in the very populations researchers use to evaluate selection's limits: populations that have experienced a recent shift in population size and/or effective recombination rates. Here we highlight theory and data analyses concerning limitations on the action of natural selection in nonequilibrial populations and argue that substantial care is needed to appropriately test whether species and populations show meaningful differences in selection efficacy. A move toward model-based inferences that explicitly incorporate nonequilibrium dynamics provides a promising approach to more accurately contrast selection efficacy across populations and interpret its significance.

PMID:
26874998
DOI:
10.1016/j.tig.2016.01.004
[Indexed for MEDLINE]

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