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J Gynecol Obstet Biol Reprod (Paris). 2016 Sep;45(7):708-15. doi: 10.1016/j.jgyn.2015.12.005. Epub 2016 Feb 10.

[Association between oxytocin augmentation intervals and the risk of postpartum haemorrhage].

[Article in French]

Author information

1
Maternité Port-Royal, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 53, avenue de l'Observatoire, 75014 Paris, France; École de sages-femmes Baudelocque, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 75014 Paris, France. Electronic address: clemence.loscul@cch.aphp.fr.
2
École de sages-femmes Baudelocque, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 75014 Paris, France; Inserm UMR 1153, équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), centre de recherche épidémiologie et statistique Sorbonne Paris Cité, DHU risques et grossesse, université Paris Descartes, 75014 Paris, France.
3
Maternité Port-Royal, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 53, avenue de l'Observatoire, 75014 Paris, France.
4
Inserm UMR 1153, équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), centre de recherche épidémiologie et statistique Sorbonne Paris Cité, DHU risques et grossesse, université Paris Descartes, 75014 Paris, France.
5
Maternité Port-Royal, hôpital Cochin, Assistance publique-Hôpitaux de Paris, 53, avenue de l'Observatoire, 75014 Paris, France; Inserm UMR 1153, équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), centre de recherche épidémiologie et statistique Sorbonne Paris Cité, DHU risques et grossesse, université Paris Descartes, 75014 Paris, France.

Abstract

OBJECTIVE:

To study the association between the duration of oxytocin augmentation intervals and the risk of postpartum haemorrhage (PPH) among primiparous women in spontaneous labour.

MATERIALS AND METHODS:

Retrospective cohort including primiparous women in spontaneous labour who received oxytocin during labour (n=454). Oxytocin augmentation intervals were dichotomized in intervals<20minutes and≥20minutes. Obstetrical and neonatal issues were analyzed according to the duration oxytocin augmentation intervals. The association between oxytocin augmentation intervals and PPH was analyzed using univariate and multivariate analysis.

RESULTS:

Oxytocin augmentation intervals were shorter than 20minutes for 43.8% of the study population. The rate of PPH was higher (9.1% vs 3.5%; P=0.014), and the use of sulprostone was more frequent (6.5% vs 3.5%; P=0.013) if oxytocin augmentation intervals were shorter than 20minutes in comparison with intervals≥20minutes. The association between oxytocin augmentation intervals and PPH remains significant after adjustment on other PPH risk factors (adjusted OR=3.48, 95% CI [1.45-8.34]). The rate of adverse neonatal issue, defined by arterial pH at birth≤7.10 and/or 5minutes score d'Apgar≤7, was higher if oxytocin augmentation intervals were<20minutes (12.1% vs 4.3%; P=0.002).

CONCLUSION:

Our study demonstrated an increased risk of PPH for primiparous women in spontaneous labour who received oxytocin with augmentation intervals shorter than 20minutes.

KEYWORDS:

Augmentation intervals; Hémorragie du post-partum; Intervalles d’augmentation; Oxytocin; Oxytocine; Postpartum haemorrhage

PMID:
26874663
DOI:
10.1016/j.jgyn.2015.12.005
[Indexed for MEDLINE]
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