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Gen Comp Endocrinol. 2016 Mar 1;228:60-68. doi: 10.1016/j.ygcen.2016.02.012. Epub 2016 Feb 10.

Corticotropin-releasing hormone: Mediator of vertebrate life stage transitions?

Author information

1
Department of Anatomy, Physiology and Microbiology, La Trobe University, Bundoora, Victoria 3086, Australia. Electronic address: y.watanabe@latrobe.edu.au.
2
Department of Anatomy, Physiology and Microbiology, La Trobe University, Bundoora, Victoria 3086, Australia. Electronic address: s.grommen@latrobe.edu.au.
3
Department of Anatomy, Physiology and Microbiology, La Trobe University, Bundoora, Victoria 3086, Australia. Electronic address: b.degroef@latrobe.edu.au.

Abstract

Hormones, particularly thyroid hormones and corticosteroids, play critical roles in vertebrate life stage transitions such as amphibian metamorphosis, hatching in precocial birds, and smoltification in salmonids. Since they synergistically regulate several metabolic and developmental processes that accompany vertebrate life stage transitions, the existence of extensive cross-communication between the adrenal/interrenal and thyroidal axes is not surprising. Synergies of corticosteroids and thyroid hormones are based on effects at the level of tissue hormone sensitivity and gene regulation. In addition, in representative nonmammalian vertebrates, corticotropin-releasing hormone (CRH) stimulates hypophyseal thyrotropin secretion, and thus functions as a common regulator of both the adrenal/interrenal and thyroidal axes to release corticosteroids and thyroid hormones. The dual function of CRH has been speculated to control or affect the timing of vertebrate life history transitions across taxa. After a brief overview of recent insights in the molecular mechanisms behind the synergic actions of thyroid hormones and corticosteroids during life stage transitions, this review examines the evidence for a possible role of CRH in controlling vertebrate life stage transitions.

KEYWORDS:

Corticosteroid; Corticotropin-releasing hormone; Metamorphosis; Thyroid hormone; Thyrotropin; Vertebrate life stage transition

PMID:
26874222
DOI:
10.1016/j.ygcen.2016.02.012
[Indexed for MEDLINE]

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