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Trends Biochem Sci. 2016 Mar;41(3):219-230. doi: 10.1016/j.tibs.2016.01.002. Epub 2016 Feb 10.

Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies.

Author information

1
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112-5650, USA.
2
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112-5650, USA; Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84112-5650, USA. Electronic address: rutter@biochem.utah.edu.

Abstract

Dysregulated metabolism is an emerging hallmark of cancer, and there is abundant interest in developing therapies to selectively target these aberrant metabolic phenotypes. Sitting at the decision-point between mitochondrial carbohydrate oxidation and aerobic glycolysis (i.e., the 'Warburg effect'), the synthesis and consumption of pyruvate is tightly controlled and is often differentially regulated in cancer cells. This review examines recent efforts toward understanding and targeting mitochondrial pyruvate metabolism, and addresses some of the successes, pitfalls, and significant challenges of metabolic therapy to date.

KEYWORDS:

cancer; metabolic flexibility; metabolic heterogeneity; metabolism; pyruvate; stem cells

PMID:
26873641
PMCID:
PMC4783264
[Available on 2017-03-01]
DOI:
10.1016/j.tibs.2016.01.002
[Indexed for MEDLINE]
Free PMC Article

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