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J Evid Based Complementary Altern Med. 2017 Jan;22(1):41-46. Epub 2016 Feb 11.

Effectiveness of Anise Oil for Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome: A Randomized Active and Placebo-Controlled Clinical Trial.

Author information

1
Department of Traditional Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
2
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
3
Center for Nanotechnology in Drug Delivery and Department of Pharmaceutics, Shiraz University of Medical Sciences, Shiraz, Iran.
4
Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
5
Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
6
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Pasalar@sums.ac.ir tamaddon@sums.ac.ir.
7
Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran.
8
Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

Depression is a prevalent disorder among patients suffering from irritable bowel syndrome. The current study was performed to evaluate the effect of a traditional Persian medicine product, anise oil, in removing the symptoms of mild to moderate depression in patients with irritable bowel syndrome. In a randomized double-blinded active and placebo controlled clinical trial, 120 participants with mild to moderate depression according to the Beck Depression Inventory-II total scores were categorized into 3 equal groups and received anise oil, Colpermin, and placebo. The results at the end of trial (week 4) and follow-up (week 6) demonstrated significant priority against active and placebo groups. Although the mechanism is unknown yet, anise oil could be a promising choice of treatment for depressed patients with irritable bowel syndrome.

KEYWORDS:

anise; depression; irritable bowel syndrome; traditional Persian medicine

PMID:
26873392
PMCID:
PMC5871202
DOI:
10.1177/2156587216628374
[Indexed for MEDLINE]
Free PMC Article

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