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Am J Med Genet A. 2016 May;170A(5):1358-62. doi: 10.1002/ajmg.a.37597. Epub 2016 Feb 12.

Protein-energy malnutrition is frequent and precocious in children with cri du chat syndrome.

Author information

1
P├ędiatrie Multidisciplinaire-Nutrition de l'Enfant, CHU Poitiers, Poitiers, France.
2
Inserm, CIC1402, Poitiers, France.
3
University of Poitiers, Poitiers, France.
4
Inserm U 1069, Tours, France.
5
University of Tours, Tours, France.

Abstract

Protein-energy malnutrition (PEM) is poorly reported in cri du chat syndrome (CDCS) (OMIM #123450), a genetic disease that causes developmental delay and global growth retardation. The objective was to determine the nutritional status at different ages in children with CDCS and factors associated with PEM. A questionnaire focused on growth and nutritional care was sent to 190 families. Among 36 analyzable questionnaires, growth and nutritional indices compatible with PEM occurred in 47% of patients: 19% before 6 months of age, 24% between 6-12 months and 34% after 12 months. Eight patients received enteral feeding. Speech therapy for swallowing education was performed more often in malnourished children (63% vs. 22%, P < 0.02). PEM is frequent and occurs early in this disease, requiring closed nutritional monitoring.

KEYWORDS:

child: patient-reported outcomes; cri du chat syndrome; growth; protein-energy malnutrition

PMID:
26872355
DOI:
10.1002/ajmg.a.37597
[Indexed for MEDLINE]

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