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Br J Dermatol. 2016 May;174(5):996-1004. doi: 10.1111/bjd.14470. Epub 2016 Mar 15.

Epidemiology of chronic spontaneous urticaria: results from a nationwide, population-based study in Italy.

Author information

Health Search, Italian College of General Practitioners and Primary Care, Florence, Italy.
Dermatology and Venereology Private Practice, Bari/Barletta, Italy.
IMS Health Information Solutions Srl, Milan, Italy.
Novartis Farma S.p.A., Origgio, Varese, Italy.
Italian College of General Practitioners and Primary Care, Florence, Italy.



Chronic spontaneous urticaria (CSU) is a common skin disease, but there is a paucity of precise epidemiological data on this disease.


To obtain information on the epidemiology of CSU in Italy.


The data source was the Health Search IMS Health Longitudinal Patient Database. The study population was formed by patients aged ≥ 15 years, registered with a total of 700 general practitioners, homogeneously distributed across Italy. An algorithm based on the International Classification of Diseases, ninth revision, Clinical Modification was used for the identification of patients with CSU. The annual prevalence and incidence rates of CSU over a 12-year period (2002-2013) were estimated, along with demographic and clinical determinants.


The annual prevalence of CSU ranged from 0·02% in 2002 to 0·38% in 2013. The incidence was 0·10-1·50 per 1000 person-years. For both prevalence and incidence rates, female patients outnumbered male. The risk of CSU was statistically significantly higher in the presence of the following variables: obesity; anxiety, dissociative and somatoform disorders; malignancies; use of immunosuppressive drugs; and chronic use of systemic corticosteroids. History of autoimmune thyroiditis showed a trend towards an increased risk of CSU, though it was not statistically significant. Smoking was associated with a significantly reduced risk of CSU.


Our findings on CSU prevalence are consistent with those obtained in previous studies. Furthermore, this large population-based study provides important information regarding the association of CSU with demographic and clinical determinants, which have been examined in the primary-care setting.

[Indexed for MEDLINE]

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