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Cell. 2016 Feb 11;164(4):597-8. doi: 10.1016/j.cell.2016.01.037.

Let It Go and Open Up, an Ensemble of Ion Channel Active States.

Author information

1
Cardiovascular Research Institute, Departments of Biochemistry and Biophysics and Cellular and Molecular Pharmacology, and California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, California 94158 USA; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 USA. Electronic address: daniel.minor@ucsf.edu.

Abstract

Ligand binding usually moves the target protein from an ensemble of inactive states to a well-defined active conformation. Matthies et al. flip this scheme around, finding that, for the magnesium channel CorA, loss of ligand binding induces an ensemble of conformations that turn the channel on.

PMID:
26871624
DOI:
10.1016/j.cell.2016.01.037
[Indexed for MEDLINE]
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