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Cell. 2016 Feb 11;164(4):593-5. doi: 10.1016/j.cell.2016.01.048.

A Mechanism for Somatic Brain Mosaicism.

Author information

1
Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94305, USA. Electronic address: irv@stanford.edu.
2
The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, CA 92037, USA. Electronic address: gage@salk.edu.

Abstract

Double-strand break repair is required for neural development, and brain cells contain somatic genomic variations. Now, Wei et al. demonstrate that neural stem and progenitor cells undergo very frequent DNA breaks in a very restricted set of genes involved in neural cell adhesion and synapse function.

PMID:
26871622
DOI:
10.1016/j.cell.2016.01.048
[Indexed for MEDLINE]
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