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Acta Neurol Scand. 2016 Nov;134(5):314-326. doi: 10.1111/ane.12563. Epub 2016 Feb 12.

The genetic background of Parkinson's disease: current progress and future prospects.

Author information

1
Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
2
3rd University Department of Neurology, G. Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
3
Department of General Biology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. lfidani@med.auth.gr.

Abstract

Almost two decades of genetic research in Parkinson's disease (PD) have remarkably increased our knowledge regarding the genetic basis of PD with numerous genes and genetic loci having been found to cause familial PD or affect the risk for PD. Approximately 5-10% of PD patients have monogenic forms of the disease, exhibiting a classical Mendelian type of inheritance, however, the majority PD cases are sporadic, probably caused by a combination of genetic and environmental risk factors. Nowadays, six genes, alpha synuclein, LRRK2, VPS35, Parkin, PINK1 and DJ-1, have definitely been associated with an autosomal dominant or recessive PD mode of inheritance. The advent of genome-wide association studies (GWAS) and the implementation of new technologies, like next generation sequencing (NGS) and exome sequencing has undoubtedly greatly aided the identification on novel risk variants for sporadic PD. In this review, we will summarize the current progress and future prospects in the field of PD genetics.

KEYWORDS:

GBA; gene; lysosomes; parkinson's disease; pathway; risk factor

PMID:
26869347
DOI:
10.1111/ane.12563
[Indexed for MEDLINE]

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