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Neurochem Res. 2016 Jun;41(6):1496-504. doi: 10.1007/s11064-016-1863-7. Epub 2016 Feb 11.

Rutin Inhibits Neuroinflammation and Provides Neuroprotection in an Experimental Rat Model of Subarachnoid Hemorrhage, Possibly Through Suppressing the RAGE-NF-κB Inflammatory Signaling Pathway.

Author information

1
Institute of Neurology, The Graduate Training Base of the General Hospital of Shenyang Military Area Command of PLA of Liaoning Medical College, Shenyang, 110016, Liaoning, China.
2
Institute of Neurology, General Hospital of Shenyang Military Area Command, 83# Wenhua Road, Shenhe District, Shenyang, 110016, Liaoning, China.
3
Institute of Neurology, General Hospital of Shenyang Military Area Command, 83# Wenhua Road, Shenhe District, Shenyang, 110016, Liaoning, China. liangguobiao1965@163.com.

Abstract

As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated. In this study, we investigated the potential effects of rutin on neuroinflammation and the underlying mechanism in an experimental rat model of SAH performed by endovascular perforation. Adult male SD rats were randomly divided into three groups, including sham group, SAH + vehicle group and SAH + rutin group (50 mg/kg) intraperitoneally (i.p.) administered at 30 min after SAH. After sacrificed at 24 h after SAH, all rats were examined by following tests, including neurologic scores, blood-brain barrier permeability, brain water content and neuronal cell death in cerebral cortex. The level of inflammation in brain was estimated by means of multiple molecules, including RAGE, NF-κB, and inflammation cytokines. Our results indicated that rutin could significantly downregulate the increased level of REGE, NF-κB and inflammatory cytokines in protein level. In addition, rutin could also ameliorate a series of secondary brain injuries such as brain edema, destruction of blood-brain barrier, neurological deficits and neuronal death. This study indicated that rutin administration had a neuroprotective effect in an experimental rat model of SAH, possibly through inhibiting RAGE-NF-κB mediated inflammation signaling pathway.

KEYWORDS:

NF-κB; Neuroinflammation; RAGE; Rutin; Subarachnoid hemorrhage

PMID:
26869040
DOI:
10.1007/s11064-016-1863-7
[Indexed for MEDLINE]

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