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Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G899-905. doi: 10.1152/ajpgi.00382.2015. Epub 2016 Feb 11.

TAM receptor tyrosine kinase function and the immunopathology of liver disease.

Author information

1
Division of Digestive Diseases, Department of Medicine, Imperial College London, London, United Kingdom; and.
2
Division of Digestive Diseases, Department of Medicine, Imperial College London, London, United Kingdom; and Division of Transplantation Immunology & Mucosal Biology, Institute of Liver Sciences, King's College London, London, United Kingdom c.antoniades@imperial.ac.uk.

Abstract

Tyro3, Axl, MERTK (TAM) receptor tyrosine kinases are implicated in the regulation of the innate immune response through clearance of apoptotic cellular debris and control of cytokine signaling cascades. As a result they are pivotal in regulating the inflammatory response to tissue injury. Within the liver, immune regulatory signaling is employed to prevent the overactivation of innate immunity in response to continual antigenic challenge from the gastrointestinal tract. In this review we appraise current understanding of the role of TAM receptor function in the regulation of both innate and adaptive immunity, with a focus on its impact upon hepatic inflammatory pathology.

KEYWORDS:

Axl; Mer; Tyro3, Axl, MERTK; antitumor immunity; immune regulation

PMID:
26867565
PMCID:
PMC4935487
DOI:
10.1152/ajpgi.00382.2015
[Indexed for MEDLINE]
Free PMC Article

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