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Cell Host Microbe. 2016 Feb 10;19(2):139-41. doi: 10.1016/j.chom.2016.01.012.

SARS-CoV and IFN: Too Little, Too Late.

Author information

1
Department of Infectious Diseases and Pathobiology, University of Bern, 3012 Bern, Switzerland; Federal Department of Home Affairs, Institute of Virology and Immunology, 3012 Bern and 3147 Mittelhäusern, Switzerland.
2
Department of Infectious Diseases and Pathobiology, University of Bern, 3012 Bern, Switzerland; Federal Department of Home Affairs, Institute of Virology and Immunology, 3012 Bern and 3147 Mittelhäusern, Switzerland. Electronic address: volker.thiel@vetsuisse.unibe.ch.

Abstract

Dysregulated type I interferon (IFN-I) expression can lead to severe pathology and disease. In this issue of Cell Host & Microbe, Channappanavar et al. (2016) use a SARS-coronavirus animal model to describe how rapid and robust virus replication with delayed IFN-I can lead to lung immunopathology, with fatal outcomes.

PMID:
26867172
PMCID:
PMC7104995
DOI:
10.1016/j.chom.2016.01.012
[Indexed for MEDLINE]
Free PMC Article

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