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J Cutan Aesthet Surg. 2015 Oct-Dec;8(4):198-210. doi: 10.4103/0974-2077.172191.

Managing Complications of Fillers: Rare and Not-So-Rare.

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Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland, Europe; Department of Dermatology, Clinic Dermaticum, Freiburg, Germany, Europe; Centro de DermatologĂ­a Epidermis, Inst CUF, Porto, Portugal, Europe; Department of Dermatology, Ghent University Hospital, Gent, Belgium, Europe.


Fillers belong to the most frequently used beautifying products. They are generally well tolerated, but any one of them may occasionally produce adverse side effects. Adverse effects usually last as long as the filler is in the skin, which means that short-lived fillers have short-term side effects and permanent fillers may induce life-long adverse effects. The main goal is to prevent them, however, this is not always possible. Utmost care has to be given to the prevention of infections and the injection technique has to be perfect. Treatment of adverse effects is often with hyaluronidase or steroid injections and in some cases together with 5-fluorouracil plus allopurinol orally. Histological examination of biopsy specimens often helps to identify the responsible filler allowing a specific treatment to be adapted.


Complications; blindness; fillers; hyaluronic acid

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