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J Virol. 2016 Mar 28;90(8):4249-4253. doi: 10.1128/JVI.02501-15. Print 2016 Apr.

Inhibition of the FACT Complex Reduces Transcription from the Human Cytomegalovirus Major Immediate Early Promoter in Models of Lytic and Latent Replication.

Author information

1
Department of Microbiology and Immunology, University at Buffalo-SUNY, Buffalo, New York, USA.
2
FORGE Life Science, LLC, Baruch S. Blumberg Research Institute, Doylestown, Pennsylvania, USA.
3
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, USA.
4
FORGE Life Science, LLC, Baruch S. Blumberg Research Institute, Doylestown, Pennsylvania, USA eain.murphy@bblumberg.org.

Abstract

The successful colonization of the majority of the population by human cytomegalovirus is a direct result of the virus's ability to establish and, more specifically, reactivate from latency. The underlying cellular factors involved in viral reactivation remain unknown. Here, we show that the host complexfacilitateschromatintranscription (FACT) binds to the major immediate early promoter (MIEP) and that inhibition of this complex reduces MIEP transactivation, thus inhibiting viral reactivation.

PMID:
26865717
PMCID:
PMC4810550
DOI:
10.1128/JVI.02501-15
[Indexed for MEDLINE]
Free PMC Article

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