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J Virol. 2016 Apr 14;90(9):4827-4831. doi: 10.1128/JVI.02832-15. Print 2016 May.

Hepatitis B Virus Infection of a Mouse Hepatic Cell Line Reconstituted with Human Sodium Taurocholate Cotransporting Polypeptide.

Author information

1
Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany.
2
Key Laboratory of Medical Molecular Virology, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, Shanghai, China.
3
Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany Stephan.Urban@med.uni-heidelberg.de.
4
German Center for Infection Research (DZIF), Heidelberg, Germany.

Abstract

Hepatitis B virus (HBV) enters hepatocytes via its receptor, human sodium taurocholate cotransporting polypeptide (hNTCP). So far, HBV infection has been achieved only in human hepatic cells reconstituted with hNTCP and not in cells of mouse origin. Here, the first mouse liver cell line (AML12) which gains susceptibility to HBV upon hNTCP expression is described. Thus, HBV infection of receptor-expressing mouse hepatocytes does not principally require a human cofactor but can be triggered by endogenous murine determinants.

PMID:
26865711
PMCID:
PMC4836309
DOI:
10.1128/JVI.02832-15
[Indexed for MEDLINE]
Free PMC Article

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