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Occup Environ Med. 2016 Apr;73(4):254-61. doi: 10.1136/oemed-2015-102964. Epub 2016 Feb 10.

Welding, a risk factor of lung cancer: the ICARE study.

Author information

1
Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Equipe Epidémiologie des cancers, gènes et environnement, Villejuif, France Faculté de médecine, Université Paris Est Créteil, Créteil, France Centre Hospitalier Intercommunal, Service de Pneumologie et Pathologie Professionnelle, Créteil, France.
2
Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Equipe Epidémiologie des cancers, gènes et environnement, Villejuif, France.
3
Unité Mixte de Recherche Épidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE), Université Claude Bernard Lyon 1, Lyon, France.
4
INSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France UPMC Université de la Sorbonne, Université Paris 06, UMRS 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France.
5
Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Equipe Epidémiologie des cancers, gènes et environnement, Villejuif, France Faculté de chirurgie dentaire, Université Paris Descartes, Montrouge, France.
6
Registre des tumeurs du Doubs et du territoire de Belfort, Centre Hospitalier Universitaire de Besançon, Besançon, France.
7
INSERM U1085, IRSET, campus de Fouillole, Pointe à Pitre, Guadeloupe Université de Rennes 1, campus de Fouillole, Pointe à Pitre, Guadeloupe.

Abstract

OBJECTIVES:

We investigated the relationship between lung cancer and occupational exposure to welding activity in ICARE, a population-based case-control study.

METHODS:

Analyses were restricted to men (2276 cases, 2780 controls). Welding exposure was assessed through detailed questionnaires, including lifelong occupational history. ORs were computed using unconditional logistic regression, adjusted for lifelong cigarette smoking and occupational exposure to asbestos.

RESULTS:

Among the regular welders, welding was associated with a risk of lung cancer (OR=1.7, 95% CI 1.1 to 2.5), which increased with the duration (OR=2.0, 95% CI 1.0 to 3.9 when duration >10 years), and was maximum 10-20 years since last welding. The risk was more pronounced in case of gas welding (OR=2.0, 95% CI 1.2 to 3.3), when the workpiece was covered by paint, grease, or other substances (OR=2.0, 95% CI 1.2 to 3.4) and when it was cleaned with chemical substances before welding. No statistically significant increase in lung cancer risk was observed among occasional welders.

CONCLUSIONS:

Although these results should be confirmed, we showed that type of welding and mode of workpiece preparation are important determinants of the lung cancer risk in regular welders.

PMID:
26865654
DOI:
10.1136/oemed-2015-102964
[Indexed for MEDLINE]

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