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Laryngoscope. 2016 Jun;126(6):E213-7. doi: 10.1002/lary.25907. Epub 2016 Feb 10.

Wound-healing factors can prime head and neck cancer cells to increase their tumor-forming capacity.

Author information

1
Department of Clinical Sciences, Division of Otolaryngology/Head and Neck Surgery, Lund University, Lund, Sweden, Skåne University Hospital, Lund, Sweden.
2
Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, and Skåne University Hospital, Lund, Sweden.

Abstract

OBJECTIVES/HYPOTHESIS:

We investigated whether exposing a wound-healing-sensitive cell line to human wound fluid (HWF) could prime the cells to increase their tumor-forming ability in nude mice and, if so, whether this ability can be inhibited by pharmacological substances.

STUDY DESIGN:

Experimental animal model.

METHODS:

Take rate was measured in BALB/c nude mice after pretreatment of the cells with HWF using human serum and fetal bovine serum as controls. Inhibition of signal transducer and activator of transcription 3 (STAT3) with S3I-201 tocilizumab, and of interleukin 6 receptor (IL6R) with tocilizumab was performed.

RESULTS:

Preincubation with HWF resulted in a significant increase in take rate compared to controls. The increase in take rate could be decreased by both STAT3 and IL6R inhibition.

CONCLUSIONS:

The results indicate that head and neck squamous cell cancer cells might be stimulated to increase their tumor-forming ability both close to a surgical wound and at more distant locations, as a consequence of the wound-healing response. The work also suggests new treatment modalities aimed at decreasing these stimulatory effects.

LEVEL OF EVIDENCE:

NA Laryngoscope, 126:E213-E217, 2016.

KEYWORDS:

Head and neck squamous cell carcinoma; interleukin 6 receptor; metastasis; signal transducer and activator of transcription 3; tocilizumab; wound healing

PMID:
26865530
DOI:
10.1002/lary.25907
[Indexed for MEDLINE]

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