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Nat Rev Neurosci. 2016 Mar;17(3):183-95. doi: 10.1038/nrn.2015.26. Epub 2016 Feb 11.

Dopamine reward prediction-error signalling: a two-component response.

Author information

1
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK.

Abstract

Environmental stimuli and objects, including rewards, are often processed sequentially in the brain. Recent work suggests that the phasic dopamine reward prediction-error response follows a similar sequential pattern. An initial brief, unselective and highly sensitive increase in activity unspecifically detects a wide range of environmental stimuli, then quickly evolves into the main response component, which reflects subjective reward value and utility. This temporal evolution allows the dopamine reward prediction-error signal to optimally combine speed and accuracy.

PMID:
26865020
PMCID:
PMC5549862
DOI:
10.1038/nrn.2015.26
[Indexed for MEDLINE]
Free PMC Article

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