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Chem Commun (Camb). 2016 Mar 4;52(18):3717-20. doi: 10.1039/c5cc09540a.

In vivo monitoring of local pH values in a live rat brain based on the design of a specific electroactive molecule for H(+).

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Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China.


pH plays an important role in the biochemical, ion-regulatory, or electrical machinery of nerve and glial cells, and is considered to be related to a number of degenerative diseases. Herein, we first develop a two-channel electrochemical ratiometric biosensor for local pH determination in a live rat brain, and report the accurate pH values in the different regions of live brains upon global cerebral ischemia.


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