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Br J Radiol. 2016;89(1061):20151030. doi: 10.1259/bjr.20151030. Epub 2016 Feb 11.

Imaging genomics in cancer research: limitations and promises.

Author information

1
1 Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
2
2 Department of Neurology, The Second Xiangya Hospital, Changsha, Hunan, China.
3
3 Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
4
4 Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
5
5 Abramson Family Cancer Research Institute, PerelmanSchool of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
6
6 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Abstract

Recently, radiogenomics or imaging genomics has emerged as a novel high-throughput method of associating imaging features with genomic data. Radiogenomics has the potential to provide comprehensive intratumour, intertumour and peritumour information non-invasively. This review article summarizes the current state of radiogenomic research in tumour characterization, discusses some of its limitations and promises and projects its future directions. Semi-radiogenomic studies that relate specific gene expressions to imaging features will also be briefly reviewed.

PMID:
26864054
PMCID:
PMC4985482
DOI:
10.1259/bjr.20151030
[Indexed for MEDLINE]
Free PMC Article
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