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Can J Physiol Pharmacol. 2016 Apr;94(4):388-93. doi: 10.1139/cjpp-2014-0412. Epub 2015 May 13.

Chrysin treatment improves diabetes and its complications in liver, brain, and pancreas in streptozotocin-induced diabetic rats.

Author information

1
a Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
2
b Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Iran.
3
c Department of Neurosurgery, School of Medicine, Mashhad University of Medical Sciences, Iran.
4
d Department of Immunogenetics, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Chrysin (CH) is a natural flavonoid with pharmacological influences. The purpose of the current study was the assessment of possible protective effects of CH against oxidative damage in the serum, liver, brain, and pancreas of streptozotocin (STZ)- induced diabetic rats. In the present study, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, 3 CH (20, 40, 80 mg/kg/day)-treated diabetic groups. To find out the modulations of cellular antioxidant defense systems, malondialdehyde (MDA) level and antioxidant enzymes including glutathione-S-transferase (GST), superoxide dismutase (SOD), and catalase (CAT) activities were determined in the serum, liver, brain, and pancreas. STZ caused an elevation of glucose, MDA, TG, TC, LDL-C and with reduction of HDL-C, total protein, SOD, CAT, and GST in the serum, liver, brain, and pancreas (p < 0.01). The findings showed that the significant elevation in the glucose, MDA, TG, TC, LDL-C and reduction of HDL-C, total protein, SOD, CAT, and GST were ameliorated in the CH-treated diabetic groups versus to the untreated groups, in a dose dependent manner (p < 0.05). The current study offers that CH may be recovered diabetes and its complications by modification of oxidative stress.

KEYWORDS:

brain; cerveau; chrysin; chrysine; diabetes; diabète; foie; indices oxydatifs; liver; oxidative indices; pancreas; pancréas; rat; serum; streptozotocin; streptozotocine; sérum

PMID:
26863330
DOI:
10.1139/cjpp-2014-0412
[Indexed for MEDLINE]

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