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CNS Spectr. 2017 Jun;22(3):254-257. doi: 10.1017/S1092852915000577. Epub 2016 Feb 10.

Deep brain stimulation for bipolar disorder-review and outlook.

Author information

1
1Department of Psychiatry and Psychotherapy University Hospital,Bonn,Germany.
2
2Department of Stereotactic and Functional Neurosurgery,Freiburg University Medical Center,Freiburg (i.Br.),Germany.

Abstract

Research on deep brain stimulation (DBS) for treatment-resistant psychiatric disorders has established preliminary efficacy signals for treatment-resistant depression. There are only few studies on DBS that included patients suffering from bipolar disorder. This article gives an overview of these studies concerning DBS targets, antidepressant efficacy, and the occurrence of manic/hypomanic symptoms under stimulation. First, promising results show that all patients experienced significant improvement in depressive symptomatology. In a single case, hypomanic symptoms occurred, but they could be resolved by adjusting stimulation parameters. Furthermore, this article highlights important clinical differences between unipolar and bipolar depression that have to be considered throughout the course of treatment.

KEYWORDS:

Bipolar disorder; deep brain stimulation; medial forebrain bundle; slMFB; treatment-resistant depression

PMID:
26863160
DOI:
10.1017/S1092852915000577
[Indexed for MEDLINE]

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