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Toxicol Int. 2015 Jan-Apr;22(1):158-9. doi: 10.4103/0971-6580.172262.

A case of Trientine Overdose.

Author information

  • 1Digestive Diseases Centre, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom.

Abstract

Wilson disease is a rare genetic hepatic and neurological disorder of copper accumulation. Trientine is usually used as a second line in the management of patients with this condition. We present a case of a large overdose of Trientine (60 g) resulting in self-limiting dizziness and vomiting with no further clinical sequelae or significant biochemical abnormalities. This case shows that Trientine has a good safety profile and hence could be used as a first line treatment in patients with Wilson's disease who suffer from psychiatric complications and who might be at risk of self-harm.

KEYWORDS:

Overdose; Wilson's disease; trientine

PMID:
26862278
PMCID:
PMC4721165
DOI:
10.4103/0971-6580.172262
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