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Biomark Med. 2016;10(3):255-64. doi: 10.2217/bmm.15.118. Epub 2016 Feb 9.

Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease.

Author information

Neurovascular Surgery Program, Section of Neurosurgery, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.
Recursion Pharmaceuticals, Salt Lake City, UT 84108, USA.
Division of Cardiology & Department of Medicine at the University of Utah School of Medicine, 30 N 1900 E, Salt Lake City, UT 84132, USA.
Section of Cardiology, The University of Chicago Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.



To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically.


A prospective case-control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains.


Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features.


Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.


aggressiveness; biomarker; cerebral cavernous malformation; inflammation; non-HDL cholesterol; vitamin D

[Available on 2017-03-01]
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

Financial & competing interests disclosure This work was supported by the NIH/NINDS research grant R21 NS087328 to IA Awad, the NIH National Center for Advancing Translational Sciences grants UL1 RR024999 and UL1 TR000430 to the University of Chicago, the Scientist Development Grant of the American Heart Association (AHA-11SDG4890009) to C Shi and the Safadi Translational Research Fellowship at the University of Chicago to R Girard. The current address for C Shi is Department of Neurosurgery at The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. The sponsors had no input in the study design or data analysis. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

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