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Curr Opin Struct Biol. 2016 Apr;37:123-33. doi: 10.1016/j.sbi.2016.01.008. Epub 2016 Feb 7.

Translation regulation via nascent polypeptide-mediated ribosome stalling.

Author information

1
Gene Center and Department of Biochemistry, Feodor-Lynenstr. 25, 81377 Munich, Germany; Center for Integrated Protein Science, Munich (CiPSM), Feodor-Lynenstr. 25, 81377 Munich, Germany. Electronic address: Wilson@lmb.uni-muenchen.de.
2
Gene Center and Department of Biochemistry, Feodor-Lynenstr. 25, 81377 Munich, Germany.
3
Gene Center and Department of Biochemistry, Feodor-Lynenstr. 25, 81377 Munich, Germany; Center for Integrated Protein Science, Munich (CiPSM), Feodor-Lynenstr. 25, 81377 Munich, Germany. Electronic address: Beckmann@lmb.uni-muenchen.de.

Abstract

As the nascent polypeptide chain is being synthesized, it passes through a tunnel within the large ribosomal subunit. Interaction between the nascent polypeptide chain and the ribosomal tunnel can modulate the translation rate and induce translational stalling to regulate gene expression. In this article, we highlight recent structural insights into how the nascent polypeptide chain, either alone or in cooperation with co-factors, can interact with components of the ribosomal tunnel to regulate translation via inactivating the peptidyltransferase center of the ribosome and inducing ribosome stalling.

PMID:
26859868
DOI:
10.1016/j.sbi.2016.01.008
[Indexed for MEDLINE]

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