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Biomed Res Int. 2015;2015:840542. doi: 10.1155/2015/840542. Epub 2015 Dec 16.

Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma.

Author information

1
Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan; Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Cheng-Kung Road, Neihu, Taipei 114, Taiwan.
2
Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
3
Department of Pathology, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.
4
Department of General Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 80284, Taiwan.

Abstract

We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis. In spite of the use of chemotherapy and radiotherapy in treating HCC, patients with HCC still face poor prognosis because of the nature of multidrug resistance and toxicity derived from chemotherapy and radiotherapy. Flavonoids can be found in many vegetables, fruits, and herbal medicines that exert their different anticancer effects via different intracellular signaling pathways and serve as antioxidants. In this review, we will discuss seven common flavonoids that exert different biological effects against HCC via different pathways.

PMID:
26858957
PMCID:
PMC4695650
DOI:
10.1155/2015/840542
[Indexed for MEDLINE]
Free PMC Article

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