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Saudi J Biol Sci. 2016 Jan;23(1):S22-31. doi: 10.1016/j.sjbs.2015.06.012. Epub 2015 Jun 19.

One-step synthesis of interpenetrating network hydrogels: Environment sensitivities and drug delivery properties.

Author information

1
College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
2
Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5001, Australia.
3
Department of Geology, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; Faculty of Science & Natural Resources, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia.

Abstract

A novel interpenetrating network hydrogel for drug controlled release, composed of modified poly(aspartic acid) (KPAsp) and carboxymethyl chitosan (CMCTS), was prepared in aqueous system. The surface morphology and composition of hydrogels were characterized by SEM and FTIR. The swelling properties of KPAsp, KPAsp/CMCTS semi-IPN and KPAsp/CMCTS IPN hydrogels were investigated and the swelling dynamics of the hydrogels was analyzed based on the Fickian equation. The pH, temperature and salt sensitivities of hydrogels were further studied, and the prepared hydrogels showed extremely sensitive properties to pH, temperature, the ionic salts kinds and concentration. The results of controlled drug release behaviors of the hydrogels revealed that the introduction of IPN observably improved the drug release properties of hydrogels, the release rate of drug from hydrogels can be controlled by the structure of the hydrogels and pH value of the external environment, a relative large amount of drug released was preferred under simulated intestinal fluid. These results illustrated high potential of the KPAsp/CMCTS IPN hydrogels for application as drug carriers.

KEYWORDS:

Carboxymethyl chitosan; Drug release; Hydrogel; IPN; Poly(aspartic acid)

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