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J Cell Biol. 2016 Feb 15;212(4):379-87. doi: 10.1083/jcb.201511036. Epub 2016 Feb 8.

Metabolic regulation of mitochondrial dynamics.

Author information

1
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390.
2
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125 dchan@caltech.edu.

Abstract

Mitochondria are renowned for their central bioenergetic role in eukaryotic cells, where they act as powerhouses to generate adenosine triphosphate from oxidation of nutrients. At the same time, these organelles are highly dynamic and undergo fusion, fission, transport, and degradation. Each of these dynamic processes is critical for maintaining a healthy mitochondrial population. Given the central metabolic function of mitochondria, it is not surprising that mitochondrial dynamics and bioenergetics reciprocally influence each other. We review the dynamic properties of mitochondria, with an emphasis on how these processes respond to cellular signaling events and how they affect metabolism.

PMID:
26858267
PMCID:
PMC4754720
DOI:
10.1083/jcb.201511036
[Indexed for MEDLINE]
Free PMC Article

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