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Clin Chest Med. 2016 Mar;37(1):83-96. doi: 10.1016/j.ccm.2015.11.001. Epub 2015 Dec 23.

Nontuberculous Mycobacterial Infections in Cystic Fibrosis.

Author information

1
Department of Pediatrics, Children's Hospital Colorado, University of Colorado Denver School of Medicine, 13123 East 16th Avenue, Box B-395, Aurora, CO 80045, USA.
2
Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA; Department of Medicine, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, Aurora, CO 80045, USA.
3
Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA; Department of Medicine, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, Aurora, CO 80045, USA. Electronic address: daleyc@njhealth.org.

Abstract

Nontuberculous mycobacteria (NTM) are important emerging cystic fibrosis (CF) pathogens, with estimates of prevalence ranging from 6% to 13%. Diagnosis of NTM disease in patients with CF is challenging, as the infection may remain indolent in some, without evidence of clinical consequence, whereas other patients suffer significant morbidity and mortality. Treatment requires prolonged periods of multiple drugs and varies depending on NTM species, resistance pattern, and extent of disease. The development of a disease-specific approach to the diagnosis and treatment of NTM infection in CF patients is a research priority, as a lifelong strategy is needed for this high-risk population.

KEYWORDS:

Cystic fibrosis; Mycobacterium abscessus complex; Mycobacterium avium complex; Nontuberculous mycobacteria

PMID:
26857770
DOI:
10.1016/j.ccm.2015.11.001
[Indexed for MEDLINE]

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