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Crit Rev Anal Chem. 2016;46(1):1-14. doi: 10.1080/10408347.2014.929487.

Current Applications of Chromatographic Methods in the Study of Human Body Fluids for Diagnosing Disorders.

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a Department of Chemistry , Institute of General and Ecological Chemistry, Lodz University of Technology , Lodz , Poland.


Currently, analysis of various human body fluids is one of the most essential and promising approaches to enable the discovery of biomarkers or pathophysiological mechanisms for disorders and diseases. Analysis of these fluids is challenging due to their complex composition and unique characteristics. Development of new analytical methods in this field has made it possible to analyze body fluids with higher selectivity, sensitivity, and precision. The composition and concentration of analytes in body fluids are most often determined by chromatography-based techniques. There is no doubt that proper use of knowledge that comes from a better understanding of the role of body fluids requires the cooperation of scientists of diverse specializations, including analytical chemists, biologists, and physicians. This article summarizes current knowledge about the application of different chromatographic methods in analyses of a wide range of compounds in human body fluids in order to diagnose certain diseases and disorders.


Biomarker analysis; human body fluids

[Indexed for MEDLINE]

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