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Trends Biochem Sci. 2016 Mar;41(3):261-273. doi: 10.1016/j.tibs.2016.01.001. Epub 2016 Feb 6.

Mitochondrial Cristae: Where Beauty Meets Functionality.

Author information

1
Centro Nacional de Investigaciònes Cardiovasculares Carlos III, Madrid, Spain.
2
Centro Nacional de Investigaciònes Cardiovasculares Carlos III, Madrid, Spain; Departamento de Bioquímica, Universidad Zaragoza, Zaragoza, Spain.
3
Dulbecco Telethon Institute, Venetian Institute of Molecular Medicine, Padova, Italy; Department of Biology, University of Padova, Padova, Italy. Electronic address: luca.scorrano@unipd.it.

Abstract

Mitochondrial cristae are dynamic bioenergetic compartments whose shape changes under different physiological conditions. Recent discoveries have unveiled the relation between cristae shape and oxidative phosphorylation (OXPHOS) function, suggesting that membrane morphology modulates the organization and function of the OXPHOS system, with a direct impact on cellular metabolism. As a corollary, cristae-shaping proteins have emerged as potential modulators of mitochondrial bioenergetics, a concept confirmed by genetic experiments in mouse models of respiratory chain deficiency. Here, we review our knowledge of mitochondrial ultrastructural organization and how it impacts mitochondrial metabolism.

KEYWORDS:

OXPHOS complexes and supercomplexes; cristae; mitochondrial-shaping proteins

PMID:
26857402
DOI:
10.1016/j.tibs.2016.01.001
[Indexed for MEDLINE]

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