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Lancet Infect Dis. 2016 Mar;16(3):e13-22. doi: 10.1016/S1473-3099(15)00537-X. Epub 2016 Feb 6.

Tropheryma whipplei infection and Whipple's disease.

Author information

1
Division of Internal Medicine, Krankenhaus Maria Hilf, Daun, Germany. Electronic address: t.marth@krankenhaus-daun.de.
2
Charité-University Medicine Berlin, Campus Benjamin Franklin, Division of Infectious Diseases, Berlin, Germany.
3
University Clinic of Internal Medicine III, Allgemeines Krankenhaus Vienna, Vienna, Austria.
4
First Department of Internal Medicine, IRCCS Foundation Policlinico San Matteo, University of Pavia, Pavia, Italy.

Abstract

Recent advances in medical microbiology, epidemiology, cellular biology, and the availability of an expanded set of diagnostic methods such as histopathology, immunohistochemistry, PCR, and bacterial culture have improved our understanding of the clinical range and natural course of Tropheryma whipplei infection and Whipple's disease. Interdisciplinary and transnational research activities have contributed to the clarification of the pathogenesis of the disorder and have enabled controlled trials of different treatment strategies. We summarise the current knowledge and new findings relating to T whipplei infection and Whipple's disease.

PMID:
26856775
DOI:
10.1016/S1473-3099(15)00537-X
[Indexed for MEDLINE]

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