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Prog Neurobiol. 2016 Mar-May;138-140:1-18. doi: 10.1016/j.pneurobio.2015.12.006. Epub 2016 Feb 6.

Hippocampal neurogenesis: Learning to remember.

Author information

1
Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: olazarov@uic.edu.
2
Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.

Abstract

Alzheimer's disease, the most prevalent form of dementia in the elderly, is characterized by progressive memory loss and cognitive dysfunction. It has become increasingly clear that while neuronal cell loss in the entorhinal cortex and hippocampus occurs in Alzheimer's disease, it is preceded by a long period of deficits in the connectivity of the hippocampal formation that contributes to the vulnerability of these circuits. Hippocampal neurogenesis plays a role in the maintenance and function of the dentate gyrus and hippocampal circuitry. This review will examine the evidence suggesting that hippocampal neurogenesis plays a role in cognitive function that is affected in Alzheimer's disease, will discuss the cognitive assessments used for the detection of Alzheimer's disease in humans and rodent models of familial Alzheimer's disease, and their value for unraveling the mechanism underlying the development of cognitive impairments and dementia.

KEYWORDS:

Alzheimer's disease; Behavior; Hippocampus; Learning and memory; Neurogenesis

PMID:
26855369
PMCID:
PMC4828289
[Available on 2017-03-01]
DOI:
10.1016/j.pneurobio.2015.12.006
[Indexed for MEDLINE]
Free PMC Article

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