Format

Send to

Choose Destination
Cell Metab. 2016 Mar 8;23(3):413-26. doi: 10.1016/j.cmet.2016.01.003. Epub 2016 Feb 4.

The Intestinal Immune System in Obesity and Insulin Resistance.

Author information

1
Diabetes Research Group, Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, ON M5G 1L7, Canada; Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Pathology, University Health Network, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada. Electronic address: dan.winer@uhn.ca.
2
Diabetes Research Group, Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, ON M5G 1L7, Canada; Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
3
Diabetes Research Group, Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, ON M5G 1L7, Canada.
4
Diabetes Research Group, Division of Cellular and Molecular Biology, Toronto General Research Institute, University Health Network, 101 College Street, Toronto, ON M5G 1L7, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Department of Laboratory Medicine, St. Michael's Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada. Electronic address: shawn.winer@utoronto.ca.

Abstract

Obesity and insulin resistance are associated with chronic inflammation in metabolic tissues such as adipose tissue and the liver. Recently, growing evidence has implicated the intestinal immune system as an important contributor to metabolic disease. Obesity predisposes to altered intestinal immunity and is associated with changes to the gut microbiota, intestinal barrier function, gut-residing innate and adaptive immune cells, and oral tolerance to luminal antigens. Accordingly, the gut immune system may represent a novel therapeutic target for systemic inflammation in insulin resistance. This review discusses the emerging field of intestinal immunity in obesity-related insulin resistance and how it affects metabolic disease.

PMID:
26853748
DOI:
10.1016/j.cmet.2016.01.003
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center