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Int J Radiat Oncol Biol Phys. 2016 Feb 1;94(2):404-11. doi: 10.1016/j.ijrobp.2015.10.028. Epub 2015 Oct 24.

Imaging and Data Acquisition in Clinical Trials for Radiation Therapy.

Author information

1
Imaging and Radiation Oncology Core Rhode Island, University of Massachusetts Memorial Medical Center, University of Massachusetts Medical School, Worcester, Massachusetts. Electronic address: Thomas.Fitzgerald@umassmed.edu.
2
Imaging and Radiation Oncology Core Rhode Island, University of Massachusetts Medical School, Worcester, Massachusetts.
3
Imaging and Radiation Oncology Core Houston, University of Texas MD Anderson Cancer Center, Houston, Texas.
4
Imaging and Radiation Oncology Core Philadelphia, Thomas Jefferson University, Philadelphia, Pennsylvania.
5
Imaging and Radiation Oncology Core Ohio, Wexner Medical Center, Ohio State University, Columbus, Ohio.
6
Imaging and Radiation Oncology Core St. Louis, Washington University School of Medicine, St. Louis, Missouri.
7
Imaging and Radiation Oncology Core Philadelphia, University of Pennsylvania Health System, Philadelphia, Pennsylvania.
8
Washington University School of Medicine-Radiation Oncology, St. Louis, Missouri.
9
National Cancer Institute, Clinical Radiation Oncology Branch, Rockville, Maryland.
10
Imaging and Radiation Oncology Core Rhode Island, University of Massachusetts Memorial Medical Center, University of Massachusetts Medical School, Worcester, Massachusetts.

Abstract

Cancer treatment evolves through oncology clinical trials. Cancer trials are multimodal and complex. Assuring high-quality data are available to answer not only study objectives but also questions not anticipated at study initiation is the role of quality assurance. The National Cancer Institute reorganized its cancer clinical trials program in 2014. The National Clinical Trials Network (NCTN) was formed and within it was established a Diagnostic Imaging and Radiation Therapy Quality Assurance Organization. This organization is Imaging and Radiation Oncology Core, the Imaging and Radiation Oncology Core Group, consisting of 6 quality assurance centers that provide imaging and radiation therapy quality assurance for the NCTN. Sophisticated imaging is used for cancer diagnosis, treatment, and management as well as for image-driven technologies to plan and execute radiation treatment. Integration of imaging and radiation oncology data acquisition, review, management, and archive strategies are essential for trial compliance and future research. Lessons learned from previous trials are and provide evidence to support diagnostic imaging and radiation therapy data acquisition in NCTN trials.

PMID:
26853346
PMCID:
PMC4746496
DOI:
10.1016/j.ijrobp.2015.10.028
[Indexed for MEDLINE]
Free PMC Article

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