Stimuli-responsive Smart Liposomes in Cancer Targeting

Curr Drug Targets. 2018 Feb 8;19(3):259-270. doi: 10.2174/1389450117666160208144143.

Abstract

Background: Liposomes are vesicular carriers which possess aqueous core entrapped within the lipid bilayer. These are carriers of choice because of biocompatible and biodegradable features in addition to flexibility of surface modifications at surface and lipid compositions of lipid bilayers.

Objective: Liposomes have been reported well for cancer treatment using both passive and active targeting approaches however tumor microenvironment is still the biggest hurdle for safe and effective delivery of anticancer agents. To overcome this problem, stimuli-responsive smart liposomes have emerged as promising cargoes pioneered to anomalous tumor milieu in response to pH, temperature, and enzymes etc. as internal triggers, and magnetic field, ultrasound, and redox potential as external guides for enhancement of drug delivery to tumors.

Conclusion: This review focuses on all such stimuli-responsive approaches using fabrication potentiality of liposomes in combination to various ligands, linkers, and PEGylation etc. Scientists engaged in cancer targeting approaches can get benefited greatly with this knowledgeable assemblage of advances in liposomal nanovectors.

Keywords: Stimuli-sensitive; liposomes; pH-sensitive; smart delivery; thermo-sensitive; ultrasound responsive.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / therapeutic use
  • Drug Carriers / administration & dosage
  • Drug Carriers / chemistry*
  • Drug Delivery Systems
  • Humans
  • Hydrogen-Ion Concentration
  • Liposomes / administration & dosage
  • Liposomes / chemistry*
  • Neoplasms / drug therapy*
  • Temperature
  • Tumor Microenvironment

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Liposomes