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Sci Rep. 2016 Feb 8;6:20602. doi: 10.1038/srep20602.

Intestinal Microbiota Distinguish Gout Patients from Healthy Humans.

Author information

1
Key Laboratory of Dairy Biotechnology and Bioengineering, Education Ministry of P. R. China, Huhhot, Inner Mongolia, 010018, China.
2
The First Affiliated Hospital, Baotou Medical College, Baotou, Inner Mongolia, 014010, China.
3
Department of Microbiology, Yong Loo Li School of Medicine, National University of Singapore, 5 Science Drive 2, 117597, Singapore.
4
Single-Cell Center, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong, 266101, China.

Abstract

Current blood-based approach for gout diagnosis can be of low sensitivity and hysteretic. Here via a 68-member cohort of 33 healthy and 35 diseased individuals, we reported that the intestinal microbiota of gout patients are highly distinct from healthy individuals in both organismal and functional structures. In gout, Bacteroides caccae and Bacteroides xylanisolvens are enriched yet Faecalibacterium prausnitzii and Bifidobacterium pseudocatenulatum depleted. The established reference microbial gene catalogue for gout revealed disorder in purine degradation and butyric acid biosynthesis in gout patients. In an additional 15-member validation-group, a diagnosis model via 17 gout-associated bacteria reached 88.9% accuracy, higher than the blood-uric-acid based approach. Intestinal microbiota of gout are more similar to those of type-2 diabetes than to liver cirrhosis, whereas depletion of Faecalibacterium prausnitzii and reduced butyrate biosynthesis are shared in each of the metabolic syndromes. Thus the Microbial Index of Gout was proposed as a novel, sensitive and non-invasive strategy for diagnosing gout via fecal microbiota.

PMID:
26852926
PMCID:
PMC4757479
DOI:
10.1038/srep20602
[Indexed for MEDLINE]
Free PMC Article

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