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Biosens Bioelectron. 2017 Mar 15;89(Pt 1):592-597. doi: 10.1016/j.bios.2016.01.078. Epub 2016 Jan 29.

Synthesis of ZnO nanowire arrays/3D graphene foam and application for determination of levodopa in the presence of uric acid.

Author information

1
School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin 150040, People's Republic of China. Electronic address: hyyue@hrbust.edu.cn.
2
School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin 150040, People's Republic of China.
3
Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China.

Abstract

Three-dimensional (3D) graphene foam (GF) was prepared by chemical vapor deposition (CVD) using nickel foam as the template. ZnO nanowire arrays (ZnO NWAs) were vertically grown on the 3D GF by hydrothermal synthesis to prepare ZnO NWAs/GF. This hybrid combines the properties of ZnO NWAs and 3D GF, which has favorable electrocatalysis and outstanding electrical conductivity. The vertically aligned ZnO NWAs grown on the GF enlarged the electroactive surface area, which was investigated from the Fe(CN)63-4+ redox kinetic study. The ZnO NWAs/GF was used as an electrochemical electrode for the determination of Levodopa (LD) in the presence of uric acid (UA). The electrochemical responses of the ZnO NWAs/GF electrode were investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The results show that the sensitivity of the electrode for LD is 3.15μAμM-1 in the concentration range of 0.05-20μM and the measured detection limit of the electrode for LD is 50nM. The electrode also shows good selectivity, reproducibility and stability. The proposed electrode is succsefully used to determine LD in human plasma samples and it is potential for use in clinical research.

KEYWORDS:

Electrochemical biosensors; Graphene foam; Levodopa; Uric acid; ZnO nanowire arrays

PMID:
26852156
DOI:
10.1016/j.bios.2016.01.078
[Indexed for MEDLINE]

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