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J Mol Biol. 2016 Jun 19;428(12):2569-2574. doi: 10.1016/j.jmb.2016.01.028. Epub 2016 Feb 3.

Mediator Architecture and RNA Polymerase II Interaction.

Author information

1
Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077, Göttingen, Germany.
2
Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Am Fassberg 11, 37077, Göttingen, Germany. Electronic address: patrick.cramer@mpibpc.mpg.de.

Abstract

Integrated structural biology recently elucidated the architecture of Mediator and its position on RNA polymerase II. Here we summarize these achievements and list open questions on Mediator structure and mechanism.

KEYWORDS:

RNA polymerase II; coactivator; gene transcription; multiprotein complex

PMID:
26851380
DOI:
10.1016/j.jmb.2016.01.028
[Indexed for MEDLINE]

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