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Cancer Discov. 2016 Feb;6(2):125-7. doi: 10.1158/2159-8290.CD-15-1470.

Adenoid Cystic Carcinoma Can Be Driven by MYB or MYBL1 Rearrangements: New Insights into MYB and Tumor Biology.

Author information

1
School of Pharmacy, University of Queensland, Brisbane, Queensland, Australia. t.gonda@uq.edu.au.
2
Peter MacCallum Cancer Centre, the Sir Peter MacCallum Oncology Department and the Pathology Department, University of Melbourne, Melbourne, Victoria, Australia.

Abstract

A majority of adenoid cystic carcinomas (AdCC)-rare tumors of the salivary gland and some other organs-have recently been found to be driven by chromosomal translocations resulting in MYB-NFIB fusions. Brayer and colleagues and Mitani and colleagues have now reported that AdCCs can alternatively be driven by similar rearrangements involving a second MYB family gene, MYBL1, and that these two drivers act in remarkably similar ways.

PMID:
26851182
DOI:
10.1158/2159-8290.CD-15-1470
[Indexed for MEDLINE]
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