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Anticancer Res. 2016 Feb;36(2):545-53.

Intestinal Tumor Development in C57BL/6J-ApcMin/+ Mice Expressing Human Sulphotransferases 1A1 and 1A2 After Oral Exposure to 2,5-Dimethylfuran.

Author information

1
Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway.
2
Office of the Director-General, Norwegian Institute of Public Health, Oslo, Norway.
3
Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway trine.husoy@fhi.no.

Abstract

BACKGROUND:

2,5-dimethylfuran (DMF) is formed during heating of foods. Following side chain hydroxylation, DMF could be a substrate for human sulphotransferases (SULTs), which may lead to formation of a DNA reactive electrophile. Only few conflicting in vitro and no in vivo studies on DMF currently exist.

MATERIALS AND METHODS:

The tumorigenic potential of DMF was studied in multiple intestinal neoplasia Apc(Min/+) (Min) mice that are sensitive to intestinal carcinogenesis and express hSULTs 1A1 and 1A2 (Min/hSULT). Min and Min/hSULT mice were orally exposed to DMF for six weeks.

RESULTS:

The intestinal tumor development of untreated female Min/hSULT mice was significantly lower compared to that of untreated Min females. No such effects of hSULTs were seen in males. DMF had a weak tumorigenic potential in the colon of female Min/hSULT mice, but not in males. Tumor development in Min mice was not affected.

CONCLUSION:

Overall, the tumorigenic potential of DMF in a metabolically competent mouse model was not convincing.

KEYWORDS:

2,5-Dimethylfuran; Min mice; SULT; human sulphotransferases; tumorigenicity

PMID:
26851008
[Indexed for MEDLINE]

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