Format

Send to

Choose Destination
Med Sci (Paris). 2016 Jan;32(1):35-44. doi: 10.1051/medsci/20163201007. Epub 2016 Feb 5.

[Epigenetics in transgenerational responses to environmental impacts: from facts and gaps].

[Article in French]

Author information

1
Inra, UMR1198, biologie du développement et reproduction, Domaine de Vilvert, Bâtiment 230, F-78350 Jouy-en-Josas, France.
2
Institut Carmen, Inserm U1060, Oullins, France.
3
Inra, UMR 1280, université de Nantes, Institut des maladies de l'appareil digestif, F-44000 Nantes, France.
4
Inserm UMR1037, Centre de recherches en cancérologie de Toulouse, Université de Toulouse III Paul Sabatier, F-31037 Toulouse, France.

Abstract

The existence of non-genetic and non-cultural mechanisms that transfer information on the memory of parental exposures to various environments, determining the reactivity of the following generations to their environments during their life, are of growing interest. Yet fundamental questions remain about the nature, the roles and relative importance of epigenetic marks and processes, non-coding RNAs, or other mechanisms, and their persistence over generations. A model incorporating the various transmission systems, their cross-talks and windows of susceptibility to the environment as a function of sex/gender of parent and offspring, has yet to be built.

PMID:
26850605
DOI:
10.1051/medsci/20163201007
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for EDP Sciences
Loading ...
Support Center