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Med Sci (Paris). 2016 Jan;32(1):27-34. doi: 10.1051/medsci/20163201006. Epub 2016 Feb 5.

[The new paradigm of the developmental origin of health and diseases (DOHaD)--Epigenetics and environment: evidence and missing links].

[Article in French]

Author information

1
Inra, UMR1198, biologie du développement et reproduction, Domaine de Vilvert, Bâtiment 230, F-78352 Jouy-en-Josas, France.
2
Inra, UMR1198, biologie du développement et reproduction, Domaine de Vilvert, Bâtiment 230, F-78352 Jouy-en-Josas, France - Université Pierre et Marie Curie, F-75005 Paris, France.
3
Institut Carmen, Inserm U1060, Oullins, France.
4
UMR 1280 Inra université de Nantes, Institut des maladies de l'appareil digestif, Nantes, France.
5
Inserm UMR1037, Centre de recherche en cancérologie de Toulouse, université de Toulouse III Paul Sabatier, F-31037 Toulouse, France.

Abstract

According to the new paradigm of the Developpemental Origins of Health and Disease (DOHaD), the environmental factors to which an individual is exposed throughout his life can leave an epigenetic footprint on the genome. A crucial period is the early development, where the epigenome is particularly sensitive to the effects of the environment, and during which the individual builds up his health capital that will enable him to respond more or less well to the vagaries of life. The research challenge is to decipher the modes of action and the epigenetic mechanisms put into play by environmental factors that lead to increased disease susceptibility or resilience. The challenge for health is to translate these scientific discoveries into action through, among others, the establishment of preventive recommendations to slow down the growing incidence of non communicable diseases.

PMID:
26850604
DOI:
10.1051/medsci/20163201006
[Indexed for MEDLINE]
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