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Med Sci (Paris). 2016 Jan;32(1):15-20. doi: 10.1051/medsci/20163201004. Epub 2016 Feb 5.

[Developmental origin of health and adult diseases (DOHaD): evolution of a concept over three decades].

[Article in French]

Author information

1
Inserm, UMR1153, centre de recherche en épidémiologie et biostatistiques, Sorbonne Paris-Cité (CRESS), équipe de recherche sur les origines précoces de la santé et du développement de l'enfant; Paris Descartes université, 16, avenue Paul Vaillant Couturier, F-94807 Villejuif, France.
2
UMR1027, université Toulouse III, équipe cancer et maladies chroniques : inégalités sociales de santé, accès primaire et secondaire aux soins, 37, allées Jules Guesde, 31069 Toulouse, France.
3
Inserm, unité 1138, université Pierre et Marie Curie UMRS 1138 et mission Inserm associations, département de l'information scientifique et de la communication, 101, rue de Tolbiac, 75013 Paris, France.

Abstract

In the 1980s, D. Barker and his team proposed the hypothesis of a fetal origin of adult diseases. The concept subsequently evolved into the developmental origins of health and diseases. Progresses in various domains such as social epidemiology, neuroscience, toxicology have contributed to establish the early years of life as a key period for future health. Finally, epigenetics has provided biological plausibility to long-term programming of health by early exposures. The convergence of all these currents has led to conceptualize human health in a complex and dynamic continuum, the Lifecourse Health Development, beginning in the prenatal period and covering the whole life. Many animal models have been developed to try to unravel the mechanisms involved. Their contributions are described in this paper with the example of type 2 diabetes.

PMID:
26850602
DOI:
10.1051/medsci/20163201004
[Indexed for MEDLINE]
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