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J Occup Environ Med. 2016 Feb;58(2):195-9. doi: 10.1097/JOM.0000000000000596.

Risk of Pancreatic Cancer in Female Textile Workers in Shanghai, China, Exposed to Metals, Solvents, Chemicals, and Endotoxin: Follow-Up to a Nested Case-Cohort Study.

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Department of Environmental and Occupational Health Sciences (Drs Gallagher, Vedal, and Checkoway); Department of Epidemiology (Drs Romano and Thomas), University of Washington; Program in Epidemiology (Drs Li and Thomas), Division of Public Health Sciences (Ms Ray), Fred Hutchinson Cancer Research Center, Seattle; Department of Epidemiology (Dr Gao), Zhongshan Hospital, Fu Dan University, Shanghai, China; and Department of Family and Preventive Medicine, University of California San Diego, La Jolla.



We studied associations between pancreatic cancer and occupational exposures to metals, solvents, chemicals, and endotoxin in a cohort of female textile workers in Shanghai, China. To assess the longer-term influences of these agents on pancreatic cancer we extended follow-up of this previously studied cohort.


We utilized a job exposure matrix to assess occupational exposures for 481 pancreatic cancer cases and a randomly selected sub-cohort of 3191 non-cases. We calculated hazard ratios and 95% confidence intervals using Cox proportional hazards modeling adapted for the case-cohort design.


We observed a statistically significant trend of increasing hazard ratios associated with solvent exposure, but no associations with any of the remaining occupational exposures, including endotoxin and metals.


Our findings of increasing risk of pancreatic cancer with solvent exposures are consistent with published literature.

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