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J Occup Environ Med. 2016 Feb;58(2):195-9. doi: 10.1097/JOM.0000000000000596.

Risk of Pancreatic Cancer in Female Textile Workers in Shanghai, China, Exposed to Metals, Solvents, Chemicals, and Endotoxin: Follow-Up to a Nested Case-Cohort Study.

Author information

1
Department of Environmental and Occupational Health Sciences (Drs Gallagher, Vedal, and Checkoway); Department of Epidemiology (Drs Romano and Thomas), University of Washington; Program in Epidemiology (Drs Li and Thomas), Division of Public Health Sciences (Ms Ray), Fred Hutchinson Cancer Research Center, Seattle; Department of Epidemiology (Dr Gao), Zhongshan Hospital, Fu Dan University, Shanghai, China; and Department of Family and Preventive Medicine, University of California San Diego, La Jolla.

Abstract

OBJECTIVE:

We studied associations between pancreatic cancer and occupational exposures to metals, solvents, chemicals, and endotoxin in a cohort of female textile workers in Shanghai, China. To assess the longer-term influences of these agents on pancreatic cancer we extended follow-up of this previously studied cohort.

METHODS:

We utilized a job exposure matrix to assess occupational exposures for 481 pancreatic cancer cases and a randomly selected sub-cohort of 3191 non-cases. We calculated hazard ratios and 95% confidence intervals using Cox proportional hazards modeling adapted for the case-cohort design.

RESULTS:

We observed a statistically significant trend of increasing hazard ratios associated with solvent exposure, but no associations with any of the remaining occupational exposures, including endotoxin and metals.

CONCLUSIONS:

Our findings of increasing risk of pancreatic cancer with solvent exposures are consistent with published literature.

PMID:
26849264
PMCID:
PMC4870312
DOI:
10.1097/JOM.0000000000000596
[Indexed for MEDLINE]
Free PMC Article

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